PNC-27 Research Peptide Lyophilized Powder

PNC-27 Research Peptide Lyophilized Powder binds to HDM-2 in a p53 peptide-like structure, inducing selective transmembrane pore formation that leads to cancer cell lysis. As an anticancer peptide, it is studied for its selective activity toward cells expressing membrane-localized HDM-2 while leaving normal cells unaffected, and is used in acute myeloid leukemia research.

Core Advantages

PNC-27 Research Peptide Lyophilized Powder is a research-grade anticancer peptide that binds membrane-expressed HDM-2 in a p53-like conformation, inducing selective transmembrane pore formation and cancer cell lysis. Its key advantage is selectivity—it targets cells with membrane-localized HDM-2 while leaving normal cells unaffected, making it a valuable tool for oncology research, including acute myeloid leukemia studies. Supplied as ≥98% HPLC-verified lyophilized powder, it delivers batch-to-batch consistency for reproducible laboratory results.

Product Specifications

Applications

1. Oncology Basic Research

PNC-27 Research Peptide Lyophilized Powder can be used in in vitro cell-based assays for tumor cell killing studies, including pancreatic cancer, breast cancer, ovarian cancer, cervical cancer, colon cancer, lung cancer, sarcoma, leukemia, and other tumor cell lines. It may also be applied in research targeting CD44+ cancer stem cells.

2. In Vivo Tumor Model Studies

PNC-27 Research Peptide Lyophilized Powder is suitable for preclinical evaluation of in vivo antitumor activity using nude mouse xenograft models. It can also be used in pharmacodynamic studies of acute myeloid leukemia (AML) animal models and in combination studies with chemotherapeutic agents such as paclitaxel to explore potential synergistic effects.

3. Preclinical Peptide Drug Development

As a novel membrane-targeted oncolytic peptide candidate, PNC-27 Research Peptide Lyophilized Powder can support the development of antitumor peptides with a distinct mechanism of action. It is also useful for investigating the molecular mechanisms of cell-penetrating peptides and membrane pore-forming peptides.

4. Cell Biology and Molecular Biology Research Tool

PNC-27 Research Peptide Lyophilized Powder can be used as a research tool to study HDM‑2 membrane localization, cell membrane structure, and the mechanism of cell necrosis. It may also support peptide structure–activity relationship analysis.

FAQ

1: What is PNC-27 Research Peptide Lyophilized Powder ?

PNC-27 is a synthetic chimeric peptide. It is supplied as lyophilized powder to improve stability during storage and transportation. This product is for research use only.

2: What is the storage requirement for PNC-27 Lyophilized Peptide

Store the unopened lyophilized powder at -20°C, protected from light and moisture. Avoid repeated freeze-thaw cycles. After reconstitution, store at 2–8°C for short-term use.

3.  How to reconstitute PNC-27?

 It is soluble in sterile water or bacteriostatic water. Add the solvent gently and mix slowly to prepare the target concentration

4.  What are the available purity grades?

≥99% (HPLC), optional as customer’s request.

5.  What package specifications can you provide

5mg, 10mg per vial. Custom packaging is available. MOQ: 1 box.

6.  What are the applications of PNC-27?

 It is used for oncology basic research, in vivo tumor model studies, preclinical peptide drug development and cell & molecular biology research.

7.  What is the shelf life under recommended storage?

36 months for unopened product stored at -20°C.